3,566 research outputs found
Evaluation of Functional Electrical Stimulation to Assist Cycling in Four Adolescents with Spastic Cerebral Palsy
Introduction. Adolescents with cerebral palsy (CP) often have difficulty participating in exercise at intensities necessary to improve cardiovascular fitness. Functional electrical stimulation- (FES-) assisted cycling is proposed as a form of exercise for adolescents with CP. The aims of this paper were to adapt methods and assess the feasibility of applying FES cycling technology in adolescents with CP, determine methods of performing cycling tests in adolescents with CP, and evaluate the immediate effects of FES assistance on cycling performance. Materials/Methods. Four participants (12–14 years old; GMFCS levels III-IV) participated in a case-based pilot study of FES-assisted cycling in which bilateral quadriceps muscles were activated using surface electrodes. Cycling cadence, power output, and heart rate were collected. Results. FES-assisted cycling was well tolerated (n = 4) and cases are presented demonstrating increased cadence (2–43 rpm), power output (19–70%), and heart rates (4-5%) and decreased variability (8–13%) in cycling performance when FES was applied, compared to volitional cycling without FES assistance. Some participants (n = 2) required the use of an auxiliary hub motor for assistance. Conclusions. FES-assisted cycling is feasible for individuals with CP and may lead to immediate improvements in cycling performance. Future work will examine the potential for long-term fitness gains using this intervention
A First Comparison of SLOPE and Other LIGO Burst Event Trigger Generators
A number of different methods have been proposed to identify unanticipated
burst sources of gravitational waves in data arising from LIGO and other
gravitational wave detectors. When confronted with such a wide variety of
methods one is moved to ask if they are all necessary, i.e. given detector data
that is assumed to have no gravitational wave signals present, do they
generally identify the same events with the same efficiency, or do they each
'see' different things in the detector? Here we consider three different
methods, which have been used within the LIGO Scientific Collaboration as part
of its search for unanticipated gravitational wave bursts. We find that each of
these three different methods developed for identifying candidate gravitational
wave burst sources are, in fact, attuned to significantly different features in
detector data, suggesting that they may provide largely independent lists of
candidate gravitational wave burst events.Comment: 10 Pages, 5 Figures, Presented at the 10th Gravitational Wave Data
Analysis Workshop (GWDAW-10), 14-17 December 2005 at the University of Texas,
Brownsvill
Utility of Surgeon-Performed Ultrasound Assessment of the Lateral Neck for Metastatic Papillary Thyroid Cancer
Ultrasound is the recommended staging modality for papillary thyroid cancer. Surgeons proficient in US assessment of the neck and experienced in the management of papillary thyroid cancer (PTC) appear uniquely qualified to assess the lateral cervical lymph nodes for metastatic disease. Of 310 patients treated for PTC between 2000 and 2008, 109 underwent surgeon-performed ultrasound (SUS) of the lateral neck preoperatively. Fine needle aspiration was performed on suspicious lateral lymph nodes. SUS findings were compared with FNA cytology and results of postoperative imaging studies. The sensitivity and negative predictive value of SUS were 88% and 97%, respectively. Four patients were found to have missed metastatic disease within 6 months. No patient underwent a nontherapeutic neck dissection. SUS combined with US-guided FNA of suspicious lymph nodes can accurately stage PTC to reliably direct surgical management
Long-term cardiovascular outcomes after pregnancy in women with heart disease
BACKGROUND: Women with heart disease are at risk for pregnancy complications, but their long-term cardiovascular outcomes after pregnancy are not known. METHODS AND RESULTS: We examined long-term cardiovascular outcomes after pregnancy in 1014 consecutive women with heart disease and a matched group of 2028 women without heart disease. The primary outcome was a composite of mortality, heart failure, atrial fibrillation, stroke, myocardial infarction, or arrhythmia. Secondary outcomes included cardiac procedures and new hypertension or diabetes mellitus. We compared the rates of these outcomes between women with and without heart disease and adjusted for maternal and pregnancy characteristics. We also determined if pregnancy risk prediction tools (CARPREG [Canadian Cardiac Disease in Pregnancy] and World Health Organization) could stratify long-term risks. At 20-year follow-up, a primary outcome occurred in 33.1% of women with heart disease, compared with 2.1% of women without heart disease. Thirty-one percent of women with heart disease required a cardiac procedure. The primary outcome (adjusted hazard ratio, 19.6; 95% CI, 13.8–29.0; P\u3c0.0001) and new hypertension or diabetes mellitus (adjusted hazard ratio, 1.6; 95% CI, 1.4–2.0; P\u3c0.0001) were more frequent in women with heart disease compared with those without. Pregnancy risk prediction tools further stratified the late cardiovascular risks in women with heart disease, a primary outcome occurring in up to 54% of women in the highest pregnancy risk category. CONCLUSIONS: Following pregnancy, women with heart disease are at high risk for adverse long-term cardiovascular outcomes. Current pregnancy risk prediction tools can identify women at highest risk for long-term cardiovascular events
Maximum Entropy for Gravitational Wave Data Analysis: Inferring the Physical Parameters of Core-Collapse Supernovae
The gravitational wave signal arising from the collapsing iron core of a Type
II supernova progenitor star carries with it the imprint of the progenitor's
mass, rotation rate, degree of differential rotation, and the bounce depth.
Here, we show how to infer the gravitational radiation waveform of a core
collapse event from noisy observations in a network of two or more LIGO-like
gravitational wave detectors and, from the recovered signal, constrain these
source properties. Using these techniques, predictions from recent core
collapse modeling efforts, and the LIGO performance during its S4 science run,
we also show that gravitational wave observations by LIGO might have been
sufficient to provide reasonable estimates of the progenitor mass, angular
momentum and differential angular momentum, and depth of the core at bounce,
for a rotating core collapse event at a distance of a few kpc.Comment: 44 pages, 12 figures; accepted version scheduled to appear in Ap J 1
April 200
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Knockdown of Ant2 Reduces Adipocyte Hypoxia And Improves Insulin Resistance in Obesity.
Decreased adipose tissue oxygen tension and increased HIF-1α expression can trigger adipose tissue inflammation and dysfunction in obesity. Our current understanding of obesity-associated decreased adipose tissue oxygen tension is mainly focused on changes in oxygen supply and angiogenesis. Here, we demonstrate that increased adipocyte O2 demand, mediated by ANT2 activity, is the dominant cause of adipocyte hypoxia. Deletion of adipocyte Ant2 improves obesity-induced intracellular adipocyte hypoxia by decreasing obesity-induced adipocyte oxygen demand, without effects on mitochondrial number or mass, or oligomycin-sensitive respiration. This led to decreased adipose tissue HIF-1α expression and inflammation with improved glucose tolerance and insulin resistance in both a preventative or therapeutic setting. Our results suggest that ANT2 may be a target for the development of insulin sensitizing drugs and that ANT2 inhibition might have clinical utility
Elasticity of semiflexible polymers with and without self-interactions
A {\it new} formula for the force vs extension relation is derived from the
discrete version of the so called {\it worm like chain} model. This formula
correctly fits some recent experimental data on polymer stretching and some
numerical simulations with pairwise repulsive potentials. For a more realistic
Lennard-Jones potential the agreement with simulations is found to be good when
the temperature is above the temperature. For lower temperatures a
plateau emerges, as predicted by some recent experimental and theoretical
results, and our formula gives good results only in the high force regime. We
briefly discuss how other kinds of self-interactions are expected to affect the
elasticity of the polymer.Comment: 8 pages, 10 figure
Clinical Study Utility of Surgeon-Performed Ultrasound Assessment of the Lateral Neck for Metastatic Papillary Thyroid Cancer
Ultrasound is the recommended staging modality for papillary thyroid cancer. Surgeons proficient in US assessment of the neck and experienced in the management of papillary thyroid cancer (PTC) appear uniquely qualified to assess the lateral cervical lymph nodes for metastatic disease. Of 310 patients treated for PTC between 2000 and 2008, 109 underwent surgeon-performed ultrasound (SUS) of the lateral neck preoperatively. Fine needle aspiration was performed on suspicious lateral lymph nodes. SUS findings were compared with FNA cytology and results of postoperative imaging studies. The sensitivity and negative predictive value of SUS were 88% and 97%, respectively. Four patients were found to have missed metastatic disease within 6 months. No patient underwent a nontherapeutic neck dissection. SUS combined with US-guided FNA of suspicious lymph nodes can accurately stage PTC to reliably direct surgical management
Probing the Local Velocity Distribution of WIMP Dark Matter with Directional Detectors
We explore the ability of directional nuclear-recoil detectors to constrain
the local velocity distribution of weakly interacting massive particle (WIMP)
dark matter by performing Bayesian parameter estimation on simulated
recoil-event data sets. We discuss in detail how directional information, when
combined with measurements of the recoil-energy spectrum, helps break
degeneracies in the velocity-distribution parameters. We also consider the
possibility that velocity structures such as cold tidal streams or a dark disk
may also be present in addition to the Galactic halo. Assuming a
carbon-tetrafluoride detector with a 30-kg-yr exposure, a 50-GeV WIMP mass, and
a WIMP-nucleon spin-dependent cross-section of 0.001 pb, we show that the
properties of a cold tidal stream may be well constrained. However, measurement
of the parameters of a dark-disk component with a low lag speed of ~50 km/s may
be challenging unless energy thresholds are improved.Comment: 38 pages, 15 figure
Gravitational Waves from a Compact Star in a Circular, Inspiral Orbit, in the Equatorial Plane of a Massive, Spinning Black Hole, as Observed by LISA
Results are presented from high-precision computations of the orbital
evolution and emitted gravitational waves for a stellar-mass object spiraling
into a massive black hole in a slowly shrinking, circular, equatorial orbit.
The focus of these computations is inspiral near the innermost stable circular
orbit (isco)---more particularly, on orbits for which the angular velocity
Omega is 0.03 < Omega/Omega_{isco} < 1. The computations are based on the
Teukolsky-Sasaki-Nakamura formalism, and the results are tabulated in a set of
functions that are of order unity and represent relativistic corrections to
low-orbital-velocity formulas. These tables can form a foundation for future
design studies for the LISA space-based gravitational-wave mission. A first
survey of applications to LISA is presented: Signal to noise ratios S/N are
computed and graphed as functions of the time-evolving gravitational-wave
frequency for representative values of the hole's mass M and spin a and the
inspiraling object's mass \mu, with the distance to Earth chosen to be r_o = 1
Gpc. These S/N's show a very strong dependence on the black-hole spin, as well
as on M and \mu. A comparison with predicted event rates shows strong promise
for detecting these waves, but not beyond about 1Gpc if the inspiraling object
is a white dwarf or neutron star. This argues for a modest lowering of LISA's
noise floor. A brief discussion is given of the prospects for extracting
information from the observed wavesComment: Physical Review D, in press; 21 pages, 9 figures, 10 tables it is
present in the RevTeX fil
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